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Selected Research Publications

Year Topic ⇕ Authors ⇕ (click to sort) Paper & Publication ⇕ (click to sort)
2022 Leprosy Diagnostic Collins, J.H., Lenz, S.M., Ray, N.A., Balagon, M.F., Hagge, D.A., Lahiri, R. and Adams, L.B., 2022. A Sensitive and Quantitative Assay to Enumerate and Measure Mycobacterium leprae Viability in Clinical and Experimental Specimens. Current Protocols, 2(2), p.e359.
2022 Leprosy Diagnostic Lenz, S.M., Ray, N.A., Lema, T., Collins, J.H., Thapa, R., Girma, S., Balagon, M., Bobosha, K., Hagge, D.A., Williams, D.L. and Scollard, D.M., 2022. Utility of a Mycobacterium leprae molecular viability assay for clinical leprosy: An analysis of cases from the Philippines, Ethiopia, and Nepal. Frontiers in Tropical Diseases, 3, p.967351.
2021 COVID-19 and leprosy De Barros, B., Lambert, S.M., Negera, E., De Arquer, G.R., Sales, A.M., Darlong, J., Dias, V.L., Rozario, B.J., Pai, V.V., Alinda, M.D. and Listiawan, M.Y., 2021. An assessment of the reported impact of the COVID-19 pandemic on leprosy services using an online survey of practitioners in leprosy referral centres. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115(12), pp.1456-1461.
2021 Leprosy Diagnostics & Epidemiology Post, E., Brandsma, W., Wagenaar, I., Alam, K., Shetty, V., Husain, S., Prakoeswa, C.R.S., Shah, M. and Tamang, K.B., 2021. Delay in Leprosy Diagnosis—A multi-center, multi-country Asian study. Leprosy Review, 92(1), pp.29-37.
2021 Reaction Post, E., Wagenaar, I., Brandsma, W., Bowers, B., Alam, K., Shetty, V., Pai, V., Husain, S., Prakoeswa, C.R.S., Astari, L. and Hagge, D., 2021. Prednisolone adverse events in the treatment and prevention of leprosy neuropathy in two large double blind randomized clinical trials. Leprosy Review, 92(3), pp.236-246.
2021 Social Science Shrestha, D., Napit, I.B., Ansari, S., Choudhury, S.M., Dhungana, B., Gill, P., Griffiths, F., Gwyther, H., Hagge, D., Kandel, S. and Puri, S., 2021. Evaluation of a self-help intervention to promote the health and wellbeing of marginalised people including those living with leprosy in Nepal: a prospective, observational, cluster-based, cohort study with controls. BMC public health, 21(1), pp.1-13.
2021 Immunology Zhou, A.X., Scriba, T.J., Day, C.L., Hagge, D.A. and Seshadri, C., 2021. A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood. PLoS neglected tropical diseases, 15(12), p.e0010018.
2020 Reaction De Barros, B., Lambert, S.M., Shah, M., Pai, V.V., Darlong, J., Rozario, B.J., Alinda, M.D., Sales, A.M., Doni, S., Hagge, D.A. and Shrestha, D., 2020. Methotrexate and prednisolone study in erythema nodosum leprosum (MaPs in ENL) protocol: a double-blind randomised clinical trial. BMJ open, 10(11), p.e037700.
2020 PEP Lenz, S.M., Collins, J.H., Ray, N.A., Hagge, D.A., Lahiri, R. and Adams, L.B., 2020. Post-exposure prophylaxis (PEP) efficacy of rifampin, rifapentine, moxifloxacin, minocycline, and clarithromycin in a susceptible-subclinical model of leprosy. PLoS Neglected Tropical Diseases, 14(9), p.e0008583.
2019 Reaction Teles, R.M., Lu, J., Tió-Coma, M., Goulart, I.M., Banu, S., Hagge, D., Bobosha, K., Ottenhoff, T.H., Pellegrini, M., Geluk, A. and Modlin, R.L., 2019. Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction. PLoS neglected tropical diseases, 13(10), p.e0007764.
2019 Reaction Tió-Coma, M., van Hooij, A., Bobosha, K., van der Ploeg-van Schip, J., Banu, S., Khadge, S., Thapa, P., Kunwar, C.B., Goulart, I.M., Bekele, Y. and Hagge, D.A., 2019. Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study. Scientific reports, 9(1), pp.1-12.
2018 Drug Resistance Cambau, E., Saunderson, P., Matsuoka, M., Cole, S.T., Kai, M., Suffys, P., Rosa, P.S., Williams, D., Gupta, U.D., Lavania, M. and Cardona-Castro, N., 2018. Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15. Clinical microbiology and infection, 24(12), pp.1305-1310.
2018 Leprosy Neuropathy Han- Siong Toh, Mahesh Shah, Jeni Maharjan, Ruby Thapa, Suwash Baral, Deanna A. Hagge, Kapil D Neupane, Indra B. Napit, Diana Lockwood. Impact of Neuropathic pain in the people affected by leprosy: Study in a leprosy referral hospital in Nepal. PLOS July 2, 2018
2018 Leprosy Drugs The Leprosy Mission World Health Organization, 2018. Guidelines for the diagnosis, treatment and prevention of leprosy.
2017 ENL Stephen L. Walker , Anna M. Sales, C. Ruth Butlin, Mahesh Shah, Armi Maghanoy, Saba M. Lambert, Joydeepa Darlong, Benjamin Jewel Rozario, Vivek V. Pai, Marivic Balagon, Shimelis N. Doni, Deanna A. Hagge, José A. C. Nery, Kapil D. Neupane, Suwash Baral, Biliom A. Sangma, Digafe T. Alembo, Abeba M. Yetaye, Belaynesh A. Hassan, Mohammed B. Shelemo, Peter G. Nicholls, Diana N. J. Lockwood, on behalf of the Erythema Nodosum Leprosum International STudy Group. A leprosy clinical severity scale for erythema nodusum Leprosum: An international, multicentre validation study of the ENLIST ENL Severity Scale. PLoS Negl Trop Dis. 2017 Jul 3;11(7):e0005716. doi: 10.1371/journal.pntd.0005716.
2017 Reaction Inge Wagenaar, Erik Post, Wim Brandsma, Bob Bowers, Khorshed Alam, Vanaja Shetty, Vivek Pai, Sajid Husain, Cita Rosita Sigit Prakoeswa, Linda Astari, Deanna Hagge, Mahesh Shah, Kapil Neupane, Krishna Bahadur Tamang, The TENLEP study group , Peter Nicholls, Jan Hendrik Richardus Effectiveness of 32 weeks versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomised controlled trial. Inge M. Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial. PLOS October 4, 2017
2017 Leprosy Diagnostic Deanna A. Hagge, Pawan Parajuli, Chhatra B. Kunwar, Divya Rana, Ruby Thapa, Kapil D. Neupane, Peter Nicholls, Linda B. Adams, Annemieke Geluk, Mahesh Shah and Indra B. Napit. Opening a can of worms: leprosy reaction status is associated with complicit neglected tropical diseases within a co-endemic population.
2016 Reaction Mayboroda OA, van Hooij A, Derks R, van den Eeden SJ, Dijkman K, Khadge S, Thapa P, Kunwar CB, Hagge DA, Geluk A. Exploratory urinary metabolomics of type 1 leprosy reactions. Int J Infect Dis. 2016 Apr;45:46-52. doi: 10.1016/j.ijid.2016.02.012. Epub 2016 Feb 26
2016 Reaction - Genetics Shah JA, Berrington WR, Vary JC Jr, Wells RD, Peterson GJ, Kunwar CB, Khadge S, Hagge DA, Hawn TR. Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist. J Infect Dis. 2016 Apr 1;213(7):1189-97. doi: 10.1093/infdis/jiv570. Epub 2015 Nov 26
2016 TB Karthyk Moganeradj, Dunstan Rajendram, Saraswoti Khadge, Pam Sonneberg, Ibrahim Abubakar, Timothy D. McHugh, Murdo Macdonald, Deanna A. Hagge, Catherine Arnold. Insertion element IS6110 based characterisation of Nepalese tuberculosis strains into different genetic lineages. 2016 Clin Microbiol Infect Dis, 1: DOI: 10.15761/CMID.1000101
2016 Neuropathy Wan EL, Rivadeniera AF, Serrano HA, Napit I, Garbino JA, Joshua J, Cardona-Castro N, Dellon AL, Theuvenet W. Protocol for a Randomised Controlled Trial Investigating Decompression for Leprous Neuropathy (The DELN Protocol). Leprosy Rev. 2016 Dec;87(4):553-61.
2016 Reaction Walker, S.L., Knight, K.L., Pai, V.V., Nicholls, P.G., Alinda, M., Butlin, C.R., Darlong, J., Hagge, D.A., Lambert, S.M., Listiawan, M.Y. and Maghanoy, A. The development of a severity scale for Erythema Nodosum Leprosum–the ENLIST ENL severity scale. Leprosy Review, 87(3), pp.332-346.
2016 ENL Walker, S.L., Knight, K.L., Pai, V.V., Nicholls, P.G., Alinda, M., Butlin, C.R., Darlong, J., Hagge, D.A., Lambert, S.M., Listiawan, M.Y. and Maghanoy, A. The development of a severity scale for Erythema Nodosum Leprosum–the ENLIST ENL severity scale. Leprosy Review, 87(3), pp.332-346.
2015 Reaction Stephen L. Walker, Marivic Balagon , Joydeepa Darlong , Shimelis N. Doni , Deanna A. Hagge , Vikas Halwai , Annamma John , Saba M. Lambert, Armi Maghanoy , Jose A. C. Nery, Kapil D. Neupane , Peter G. Nicholls , Vivek V. Pai, Pawan Parajuli , Anna M. Sales , Euzenir Sarno , Mahesh Shah, Digafe Tsegaye , Diana N. J. Lockwood , Erythema Nodosum Leprosum International Study ENLIST 1: An International Multi-centre Cross-sectional Study of the Clinical Features of Erythema Nodosum Leprosum. Group PLoS Negl Trop Dis. 2015 Sep 9;9(9):e0004065. doi: 10.1371/journal.pntd.0004065. eCollection 2015
2015 Reaction Khadge S, Banu S, Bobosha K, van der Ploeg-van Schip JJ, Goulart IM, Thapa P, Kunwar CB, van Meijgaarden KE, van den Eeden SJ, Wilson L, Kabir S, Dey H, Goulart LR, Lobato J, Carvalho W, Bekele Y, Franken KL, Aseffa A, Spencer JS, Oskam L, Otttenhoff TH, Hagge DA, Geluk A.BMC Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal. Infectious Diseases. 2015;15:477. doi:10.1186/s12879-015-1128-0.
2015 Dengue Pandey BD, Pandey K, Neupane B, Shah Y, Adhikary KP, Gautam I, Hagge DA, Morita K. Trans R Soc Persistent dengue emergence: the 7 years surrounding the 2010 epidemic in Nepal. Trop Med Hyg. 2015 Dec;109(12):775-82. doi: 10.1093/trstmh/trv087. Epub 2015 Oct 26
2014 Leprosy Diagnostics William R. Berrington, Chhatra B. Kunwar, Kapil Neupane, Susan J. F. van den Eeden, James C. Vary Jr., Glenna J. Peterson, Richard D. Wells, Annemieke Geluk, Deanna A. Hagge,Thomas R. Hawn Differential Dermal Expression of CCL17 and CCL18 in Tuberculoid and Lepromatous Leprosy. PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3263.
2014 Leprosy Diagnostics Hagge DA, Scollard DM, Ray NA, Marks VT, Deming AT, Spencer JS, Adams LB IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy. PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3149. 
2014 Leprosy Diagnostics K Bobosha, LWilson, KE Meijgaarden, Y Bekele, M Zewdie, JJ van der Ploeg- van Schip, M Abebe, J Hussein, S Khadge, DA Hagge, ES Jordanova, A Aseffa, THM Ottenhoff, and A Geluk. T-cell regulation in Lepromatous Leprosy. PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2773
2014 Leprosy Diagnostics Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB,Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study. PLoS Negl Trop Dis. 2014 May 29;8(5):e2811
2013 Integrated Health Care SF Raffe, M Thapa, S. Khadge, K Tamang, DA Hagge, DN Lockwood. Diagnosis and treatment of Leprosy Reactions in Integrated Services – the Patients’ Perspective in Nepal. PLOS NTD 2013; 7(3);e2089
2012 Leprosy Diagnostics Kidist Bobosha, Sheila Tuyet Tang, Jolien J. van der Ploeg - van Schip, Yonas Bekele, Marcia Brandao Martins, Ole Lund, Kees L.M.C. Franken, Saraswoti Khadge, Jemal Hussien, Pratibha Thapa, Chhatra Kunwar, Deanna A Hagge, Abraham Aseffa, Maria C.V. Pessolani, Geraldo M. B. Pereira, Tom H. M. Ottenhoff, and Annemieke Geluk. Mycobacterium leprae virulence-associated peptides indicate M. leprae exposure or pathogenic T-cell responses in Brazil, Ethiopia and Nepal. Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:112-23
2012 Drug Resistance Li W, Matsuoka M, Kai M, Thapa P, Khadge S, Hagge DA, Brennan PJ, Vissa V. Real-Time PCR and High-Resolution Melt Analysis for Rapid Detection of Mycobacterium leprae Drug Resistance Mutations and Strain Types. J Clin Microbiol. 2012 Mar;50(3):742-53. Epub 2011 Dec 14.
2012 Immunogenetics Linda Adams, Maria Pena, Rahul Sharma, Deanna A Hagge, Erwin Schurr and Richard Truman. Insights from Animal Models on the Immunogenetics of Leprosy. Mem Inst Oswaldo Cruz. 2012 Dec; 107 Suppl 1:197-208.
2012 Leprosy Diagnostics Mariane Martins De Araújo Stefani, Adriano Badotti Grassi, Lucas Henrique Sampaio, Ana Lucia Maroclo Sousa, Mauricio Barcelos Costa, Pauline Scheelbeek, Kapil D. Neupane, Deanna A. Hagge, Murdo Macdonald, Sang-Nae Cho, Linda Oskam & Samira Buhrer-Sékula. Comparison of two rapid tests for anti phenolic glycolipid-I serology in Brazil and Nepal. Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:124-31.
2012 Clinical Trial: Leprosy Reactions (T1R) SL Walker, PG Nicholls, S Dhakal, RA Hawksworth, M Macdonald, K Mahat , S Ruchal, S Hamal, DA Hagge, KD Neupane and DNJ Lockwood. A comparison of change in the severity score of individuals with leprosy associated nerve function impairment after treatment with corticosteroids and a retrospective physician assessment of neurological outcome. Leprosy Review. 2012 Jun; 83(2):154-63.
2012 Clinical Trial: Leprosy Reactions (T1R) Walker SL, Roberts CH, Atkinson SE, Khadge S, Macdonald M, Neupane KD, Ranjit C, Sapkota BR, Dhakal S, Hawksworth RA, Mahat K, Ruchal S, Hamal S, Hagge DA, Lockwood DN. The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions. Br J Dermatol. 2012 Feb 20.
2011 Leprosy Diagnostics Bobosha K, Van Der Ploeg-Van Schip JJ, Zewdie M, Sapkota BR, Hagge DA, Franken KL, Inbiale W, Aseffa A, Ottenhoff TH, Geluk A. Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa. Lepr Rev. 2011 Dec;82(4):445-58.
2011 Clinical Trial: Leprosy Reactions (T1R) Walker SL, Nicholls PG, Dhakal S, Hawksworth RA, Macdonald M, Mahat K, Ruchal S, Hamal S, Hagge DA, Neupane KD, Lockwood DN. A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment. PLoS Negl Trop Dis. 2011 Apr 12;5(4):e1041
2010 Leprosy Reactions: Genetics Berrington, WR, Macdonald, M, Khadge, S, Sapkota, BR, Janer, M, Hagge, DA, Kaplan, G, Hawn, TR. Common polymorphisms in NOD2 gene region are associated with leprosy and its reactive states. Journal of Infectious Diseases 2010:201: 1422-1435
2010 Genetics & Susceptibility David M. Tobin, Jay C. Vary, Jr., John P. Ray1, Gregory S. Walsh, Sarah J. Dunstan, Nguyen D. Bang, Deanna A. Hagge, Saraswoti Khadge, Mary-Claire King, Thomas R. Hawn, Cecilia B. Moens, Lalita Ramakrishna The lta4h Locus Modulates Susceptibility to Mycobacterial Infection. Cell 140: 717-730.
2010 Leprosy Reactions: Genetics Sapkota, BR, Macdonald, M, E. Ann Misch, Berrington, WR, Ranjit, C, Siddiqui, MR, Kaplan, G, Hawn, TR. Polymorphisms in TNF-alpha, MBL, and VDR and their association with leprosy and immunologic reactions. Hum Immunol. 2010 Oct;71(10):992-8
2009 Case Report: Leprosy Diagnosis Bishwa R Sapkota, Kapil D Neupane and Ram K Maharjan Single lesion multibacillary leprosy, a treatment enigma: a case report. J Med Case Reports.2009.3.8
2009 Immunology Hagge DA, Saunders BM, Ebenezer GJ, Ray NA, Marks VT, Britton WJ, Krahenbuhl JL, Adams LB. Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy. Am J Pathol. 2009 Apr;174(4):1379-89.
2009 Leprosy Transmission Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamesipour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, Cole ST. Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet. 2009 Dec;41(12):1282-9
2009 Leprosy Diagnostics Sapkota, BR et al. From Genome-Based In Silico Predictions to Ex Vivo Verification of Leprosy Diagnosis. Clin Vacc Immunol.2009.16.352-359
2008 MDT Alternatives & Dapsone Sensitivity B R Sapkota, K Shrestha, B Pandey & S. L. Walker A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone. Lepr Rev 2008.79.425-428
2008 Leprosy Reactions: Genetics E. A. Misch et al. Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction. PLoS Neglected Tropical Diseases 2008.2.e231
2008 Immunology Murdo Macdonald et al Selection of Antigens and Development of Prototype Tests for Point-of-Care Leprosy Diagnosis. Clin Vacc Immunol.2008.15.1590-1597
2008 Leprosy Diagnostics S. Dhungel, C Ranjit, BR Sapkota and M Macdonald. Role of PGL-I of M. leprae in TNF-a production by In vitro whole blood assay. Nepal Med College J 2008; 10(1): 1-3
2008 Leprosy Transmission Walker SL1, Shah M, Hubbard VG, Pradhan HM, Ghimire M. Skin disease is common in rural Nepal: results of a point prevalence study., Br J Dermatol. 2008 Feb;158(2):334-8. Epub 2007 Aug 17
2007 Dapsone Sensitivity B Pandey, K Shrestha, J Lewis, R A Hawksworth, S LWalker. Mortality due to dapsone hypersensitivity syndrome complicating multi-drug therapy for leprosy in Nepal. Tropical Doctor 2007 (July).137.162-163
2007 Leprosy & TB Diagnostics Sapkota Bishwa Raj, Ranjit Chaman and Macdonald Murdo. Rapid differentiation of mycobacterium tuberculosis and mycobacterium leprae from sputum by polymerase chain reaction. Nepal Med Coll J. 2007 Mar;9(1):12-6.
2007 Genetics Walker, S; Shah, M; Whatley, S; Badminton, M Congenital erythropoietic porphyria: a novel mutation. The British journal of dermatology, 2007.157. p. 133. ISSN 0007-0963
2006 Leprosy Drug Resistance Sapkota BR, Ranjit C and Macdonald M. Reverse Line Probe Assay for the Rapid Detection of Rifampicin Resistance in Mycobacterium leprae.Nepal Med College Journal (2006) 8(2): 122-127
2006 Leprosy Neuropathic Feet Schwarz RJ, Macdonald MRC, van der Pas M. Results of Arthrodesis in neuropathic feet. J Bone Joint Surg (Br). (2006) 88-B: 747-750
2006 Leprosy Plastic Surgery W.J. Theuvenet, A K. Gavin-Finlay, A P.W. Roche. Change of sensation in leprosy by selective meshing of the epineurium. Eur J Plast Surg (2006) 28: 393–399
2005 Leprosy Reactions (ENL) Haslett, P.A.J, P.W. Roche, C.R. Butlin, M. Macdonald, N. Shrestha, R. Manandhar, J. LeMaster, R.A. Hawksworth, M. Shah, S.A. Lubinsky, M. Albert, J. Worley, and G. Kaplan. Effective Treatment of Erythema Nodosum Leprosum with Thalidomide is Associated with Immune Stimulation. J. Infect. Dis. (2005):192, 2045- 2053
2004 Clinical Trial: Leprosy Reactions (T1R) Sharon N.S. Marlowe, Rachel A. Hawksworth, C. Ruth Butlin, Peter G. Nicholls, Diana N.J. Lockwood. Clinical outcome in a randomized controlled study comparing azathioprine and predisolone versus prednisolone alone in the treatment of severe leprosy type 1 reaction in Nepal. Trans Royal Society of Trop Med Hyg (2004) 98, 602-609
2003 Leprosy Hand Surgery Schwarz RJ, Macdonald M. Assessment of results of opponensplasty. J Hand Surg [Br]. 2003 Dec; 28(6):593-6.
2002 Leprosy Neuropathy Testing de Win MM, Theuvenet WJ, Roche PW, de Bie RA, van Mameren H. The paper grip test for screening on intrinsic muscle paralysis in the foot of leprosy patients. Int J Lepr Other Mycobact Dis. 2002 Mar; 70(1):16-24.
2002 Leprosy Reactions (T1R) Treatment Manandhar R, Shrestha N, Butlin CR, Roche PW. High levels of inflammatory cytokines are associated with poor clinical response to steroid treatment and recurrent episodes of type 1 reactions in leprosy. Clin Exp Immunol. 2002 May;128(2):333-8.
2001 Leprosy Diagnostics: Drug Resistance Honore N, Roche PW, Grosset JH, Cole ST. A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae. Lepr Rev. 2001 Dec;72(4):441-8.
2001 Leprosy Neuropathy Lemaster JW, John O, Roche PW. 'Jhum-jhum'--a common paraesthesia in leprosy. Lepr Rev. 2001 Mar;72(1):100-1.
2001 Leprosy Diagnostics Lemaster JW, Shwe T, Butlin CR, Roche PW. Prediction of 'highly skin smear positive' cases among MB leprosy patients using clinical parameters. Lepr Rev. 2001 Mar;72(1):23-8.
2001 Leprosy Foot Neuropathy Macdonald MR, Brandsma JW, Warren AG, Cross H, Schwarz RJ, Solomon S, Kazen R, Gravem PE, Shrinivasan H. Report from the workshop on the Neurologically Impaired foot: 5-9 June 2000, Green Pastures Hospital, Pokhara, Nepal. Assessment and examination of the neurologically impaired foot. Lepr Rev. 2001 Sep;72(3):254-262.
2001 Leprosy Vaccine Development Martin E, Roche PW, Triccas JA, Britton WJ. DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine. 2001 Jan 8;19(11-12):1391-6.
2001 Leprosy Vaccine Development Roche PW, Neupane KD, Failbus SS, Kamath A, Britton WJ. Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae. Int J Lepr Other Mycobact Dis. 2001 Jun;69(2):93-8.
2000 Leprosy Vaccine Development Britton WJ, Martin E, Kamath AT, Neupane KD, Roche PW. Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines. Lepr Rev. 2000 Dec;71 Suppl:S176-81.
2000 Leprosy Diagnostics Dockrell HM, Black GF, Weir RE, Fine PE. Whole blood assays for interferon-gamma: practicalities and potential for use as diagnostic tests in the field. Lepr Rev. 2000 Dec;71 Suppl:S60-2.
2000 HIV Haslett PAJ, Nixon DF, Shen Z, Larsson M, Cox WI, Manandhar R, Donahoe SM, Kaplan G. Strong Human Immunodeficiency Virus (HIV)–Specific CD4+ T Cell Responses in a Cohort of Chronically Infected Patients Are Associated with Interruptions in Anti-HIV Chemotherapy. J Infect Dis 2000:181:1264-1272
2000 Leprosy Diagnostics L.M. Robertson, P.G. Nicholls and R. Butlin. Delay in presentation and start of treatment in leprosy. Lepr Rev, 2000:71:511-516.
2000 Leprosy Diagnostics LeMaster JW, Roche P. Are we any closer to being able to measure leprosy exposure? Lepr Rev. 2000 Mar;71(1):2-4.
2000 Leprosy Diagnostics Dockrell HM, Brahmbhatt S, Robertson BD, Britton S, Fruth U, Gebre N, Hunegnaw M, Hussain R, Manandhar R, Murillo L, Pessolani MCV, Roche P, Salgado JL, Sampaio E, Shahid F, Thole JER,,and Young DB. A Postgenomic Approach to Identification of Mycobacterium leprae-Specific Peptides as T-Cell Reagents. Infect Immun, 2000:68:5846-5855
2000 Leprosy Diagnostics Manandhar R, LeMaster JW, Butlin CR, Brennan PJ, Roche PW. Interferon-gamma responses to candidate leprosy skin-test reagents detect exposure to leprosy in an endemic population. Int J Lepr Other Mycobact Dis. 2000 Mar;68(1):40-8.
2000 Leprosy Drug Resistance Roche PW, Neupane KD, Failbus SS, Butlin CR. Dapsone drug resistance in the MDT era. Int J Lepr Other Mycobact Dis. 2000 Sep;68(3):323-5.
2000 Leprosy Drug Resistance Roche PW, Shrestha N, Thomas A, Honore N, Cole ST. Rapid detection of resistance to rifampicin in Mycobacterium leprae. Lepr Rev. 2000 Dec;71 Suppl:S96-7; discussion S97-9.
2000 Leprosy Diagnostics Williams, DL., Spring, L., Harris, E., Roche, PW and Gillis, TP. The dihydropteroate synthase of Mycobacterium leprae and dapsone resistance. 2000 Antimicrobial Agents and Chemotherapy 44:1530-1537.
1999 Leprosy Reactions (ENL) Manandhar R, LeMaster JW, Roche PW. Risk factors for erythema nodosum leprosum. Int J Lepr Other Mycobact Dis. 1999 Sep;67(3):270-8.
1999 Leprosy Diagnostics Roche PW, Failbus SS, Britton WJ, Cole R. Rapid method for diagnosis of leprosy by measurements of antibodies to the M. leprae 35-kDa protein: comparison with PGL-I antibodies detected by ELISA and "dipstick" methods. Int J Lepr Other Mycobact Dis. 1999 Sep;67(3):279-86.
1999 Leprosy Footwear Ruchal SP, Butlin CR, Khadka N, Mijar K. Extra depth shoes made on special last.Lepr Rev. 1999 Sep;70(3):363-5.
1999 Leprosy Diagnostics Weir RE, Brennan PJ, Butlin CR, Dockrell HM. Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects. Clin Exp Immunol. 1999 May;116(2):263-9.
1998 Leprosy Diagnostics Manandhar, R. et al The development of new skin tests for leprosy: a tool for the eradication of leprosy. J. Nepal Med Assn 37:535-540
1998 Leprosy Conference Report Roche P, Dockrell H, Brennan P. Progress in research towards a world without leprosy. Report of a WHO meeting in Ethiopia, February 1998. Lepr Rev. 1998 Jun;69(2):151-9.
1998 Leprosy Reactions (T1R) Roche PW, Theuvenet WJ, Le Master JW, Butlin CR. Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone. Int J Lepr Other Mycobact Dis. 1998 Sep;66(3):340-7.
1998 Leprosy Diagnostics Triccas JA, Roche PW, Britton WJ. Specific serological diagnosis of leprosy with a recombinant Mycobacterium leprae protein purified from a rapidly growing mycobacterial host. J Clin Microbiol. 1998 Aug;36(8):2363-5.
1998 Leprosy Diagnostics Triccas JA, Winter N, Roche PW, Gilpin A, Kendrick KE, Britton WJ. Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein. Infect Immun. 1998 Jun;66(6):2684-90.
1998 Leprosy Diagnostics Weir RE, Butlin CR, Neupane KD, Failbus SS, Dockrell HM. Use of a whole blood assay to monitor the immune response to mycobacterial antigens in leprosy patients: a predictor for type 1 reaction onset? Lepr Rev. 1998 Sep;69(3):279-93.
1997 Leprosy Diagnostics Butlin CR, Soares D, Neupane KD, Failbus SS, Roche PW. IgM anti-phenolic glycolipid-I antibody measurements from skin-smear sites: correlation with venous antibody levels and the bacterial index. Int J Lepr Other Mycobact Dis. 1997 Dec;65(4):465-8.
1997 Leprosy Reactions (T1R) Roche PW, Le Master J, Butlin CR. Risk factors for type 1 reactions in leprosy. Int J Lepr Other Mycobact Dis. 1997 Dec;65(4):450-5.
1997 Leprosy Surgery (Eye) Soares D, Chew M. Temporalis muscle transfer in the correction of lagophthalmos due to leprosy. Lepr Rev. 1997 Mar;68(1):38-42.
1997 Leprosy Muscle Weakness Soares D, Riedel A. A simple and inexpensive pinch meter to detect subclinical weakness among leprosy patients. Lepr Rev. 1997 Mar;68(1):55-60.
1997 Leprosy Surgery (Foot) Soares D. Tibialis posterior transfer for the correction of foot drop in leprosy. Long-term outcome. J Bone Joint Surg Br. 1996 Jan;78(1):61-2.
1996 Leprosy Drug Resistance Butlin CR, Neupane KD, Failbus SS, Morgan A, Britton WJ. Drug resistance in Nepali leprosy patients. Int J Lepr Other Mycobact Dis. 1996 Jun;64(2):136-41.
1996 Leprosy Surgery (Foot) Soares D, Kimula Y. Squamous cell carcinoma of the foot arising in chronic ulcers in leprosy patients. Lepr Rev. 1996 Dec;67(4):325-9.
1996 Leprosy Diagnostics Theuvenet WJ, Miyazaki N, Roche P, Shrestha I. Cytological needle aspiration for the diagnosis of pure neural leprosy. Indian J Lepr. 1996 Jan-Mar;68(1):109-12.
1996 Leprosy Vaccine Development Triccas JA, Roche PW, Winter N, Feng CG, Butlin CR, Britton WJ. A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae. Infect Immun. 1996 Dec;64(12):5171-7.
1995 Lerposy Neuropathy Butlin CR. Does loss of nerve function equal pure neuritic leprosy? Lepr Rev. 1995 Sep;66(3):257-8.
1995 Leprosy Splints Ruchal S.P. Low cost splint made from drain pipe. Engineering in Medicine and Biology Society, 1995, 15-18 Feb 1995 Page(s):PS21 - PS22
1995 Leprosy Hands Soares D, Desar N. Hand wounds in leprosy patients. Lepr Rev. 1995 Sep;66(3):235-8.
1995 Leprosy Surgery (Foot) Soares D. Tibialis posterior transfer in the correction of footdrop due to leprosy. Leprosy Rev. 1995 Sep;66(3):229-34.
1995 Leprosy Relapse Soares DJ, Neupane K, Britton WJ. Relapse with multibacillary leprosy caused by rifampicin sensitive organisms following paucibacillary multidrug therapy. Lepr Rev. 1995 Sep;66(3):210-3.
1994 Leprosy Diagnostics Adams E, Britton W, Morgan A, Sergeantson S, Basten A. Individuals from different populations identify multiple and diverse T-cell determinants on mycobacterial HSP70. Scand J Immunol. 1994 Jun;39(6):588-96.
1994 Leprosy Diagnostics Roche PW, Peake PW, Davenport MP, Britton WJ. Identification of a Mycobacterium leprae-specific T cell epitope on the 70 kDa heat shock protein. Immunol Cell Biol. 1994 Jun;72(3):215-21.
1994 TB Roche PW, Triccas JA, Avery DT, Fifis T, Billman-Jacobe H, Britton WJ. Differential T cell responses to mycobacteria-secreted proteins distinguish vaccination with bacille Calmette-Guerin from infection with Mycobacterium tuberculosis. J Infect Dis. 1994 Nov;170(5):1326-30.
1994 Leprosy Diagnostics Soares DJ, Failbus S, Chalise Y, Kathet B. The role of IgM antiphenolic glycolipid-1 antibodies in assessing household contacts of leprosy patients in a low endemic area. Lepr Rev. 1994 Dec;65(4):300-4.
1994 Leprosy Splints Theuvenet WJ, Ruchal SP, Soares DJ, Roche P. Advantages, indications, and the manufacturing of melted PVC waterpipe splints. Lepr Rev. 1994 Dec;65(4):385-95.
1994 Leprosy Survey Theuvenet WJ, Soares D, Baral JP, Theuvenet-Schutte AR, Palla JP, Jesudasan K, Nakami J, Bista RB, Jayakumar P, Failbus PK. Mass survey of leprosy in Lalitpur district, Nepal. Int J Lepr Other Mycobact Dis. 1994 Jun;62(2):256-62.
1994 Leprosy Diagnostics & Epidemiology Weir RE, Morgan AR, Britton WJ, Butlin CR, Dockrell HM. Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity. J Immunol Methods. 1994 Nov 10;176(1):93-101.
1993 Leprosy Diagnostics Adams E, Britton WJ, Morgan A, Goodsall AL, Basten A. Identification of human T cell epitopes in the Mycobacterium leprae heat shock protein 70-kD antigen. Clin Exp Immunol. 1993 Dec;94(3):500-6.
1993 Leprosy Nasal Butlin CR. Comment: nasal myiasis in leprosy. Lepr Rev. 1993 Jun;64(2):172.
1993 Leprosy Diagnostics Peake PW, Britton WJ, Davenport MP, Roche PW, and McKenzie KR Analysis of B-Cell Epitopes in the Variable C-Terminal Region of the Mycobacterium leprae 70-Kilodalton Heat Shock Protein. Infect Immun 1993:61:135-141
1993 Leprosy Drug Treatment Roche PW, Britton WJ, Failbus SS, Neupane KD, Theuvenet WJ. Serological monitoring of the response to chemotherapy in leprosy patients. Int J Lepr Other Mycobact Dis. 1993 Mar;61(1):35-43.
1993 Leprosy Neuropathy Theuvenet WJ, Finlay K, Roche P, Soares D, Kauer JM. Neuritis of the lateral femoral cutaneous nerve in leprosy. Int J Lepr Other Mycobact Dis. 1993 Dec;61(4):592-6.
1993 Leprosy Diagnostics Theuvenet WJ, Miyazaki N, Roche P, Shrestha I. Cytological needle aspiration of the nerve for the diagnosis of pure neural leprosy. Int J Lepr Other Mycobact Dis. 1993 Dec;61(4):597-9.
1992 Leprosy Diagnostics Mullins RJ, Roche P, Adams E, Jones P, Chen S, Theuvenet W, Basten A. Limiting dilution analysis in leprosy. Immunol Cell Biol. 1992 Aug;70 ( Pt 4):277-90.
1992 Leprosy Diagnostics Roche PW, Neupane KD, Britton WJ. Cellular immune response to the cell walls of Mycobacterium leprae in leprosy patients and healthy subjects exposed to leprosy. Clin Exp Immunol. 1992 Jul;89(1):110-4.
1992 Leprosy Diagnostics Roche PW, Prestidge RL, Watson JD, Britton WJ. Antibody responses to the 18-kDa protein of Mycobacterium leprae in leprosy and tuberculosis patients. Int J Lepr Other Mycobact Dis. 1992 Jun;60(2):201-7.
1992 Leprosy Diagnostics Roche PW, Theuvenet WJ, Britton WJ. Cellular immune responses to mycobacterial heat shock proteins in Nepali leprosy patients and controls. Int J Lepr Other Mycobact Dis. 1992 Mar;60(1):36-43.
1991 Leprosy & TB Diagnostics Bothamley, G. et al. Antibodies to M. tuberculosis specific epitopes in lepromatous leprosy. Clinical & Experimental Immunology 86: 426-432.
1991 Clinical Trial: LL Treatment Kaplan G, Britton WJ, Hancock GE, Theuvenet WJ, Smith KA, Job CK, Roche PW, Molloy A, Burkhardt R, Barker J, et al. The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. J Exp Med. 1991 Apr 1;173(4):993-1006.
1991 Leprosy Diagnostics Roche PW, Britton WJ, Failbus SS, Theuvenet WJ, Lavender M, Adiga RB. Serological responses in primary neuritic leprosy. Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):299-302.
1991 Clinical Trial: Leprosy Drugs Roche PW, Britton WJ, Neupane KD, Failbus SS, Cho SN, Theuvenet WJ. The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients. Am J Trop Med Hyg. 1991 Jun;44(6):702-8.
1991 Leprosy Reactions (T1R) Roche PW, Theuvenet WJ, Britton WJ. Risk factors for type-1 reactions in borderline leprosy patients. Lancet. 1991 Sep 14;338(8768):654-7.
1990 Leprosy Vaccine Development Roche PW, Theuvenet WJ, Britton WJ. Risk factors for type-1 reactions in borderline leprosy patients. Lancet. 1991 Sep 14;338(8768):654-7.
1990 Leprosy Reactions (T1R) Roche PW, Theuvenet WJ, Britton WJ. Risk factors for type-1 reactions in borderline leprosy patients. Lancet. 1991 Sep 14;338(8768):654-7.
1990 Leprosy Vaccine Development Kurlberg G. Research in developing countries: will leprosy vaccine be produced in Nepal? Nord Med. 1990;105(12):338-9. Swedish.
1990 Leprosy Diagnostics Roche PW, Britton WJ, Failbus SS, Ludwig H, Theuvenet WJ, Adiga RB. Heterogeneity of serological responses in paucibacillary leprosy--differential responses to protein and carbohydrate antigens and correlation with clinical parameters. Int J Lepr Other Mycobact Dis. 1990 Jun;58(2):319-27.
1990 Leprosy Diagnostics Roche PW, Britton WJ, Failbus SS, Williams D, Pradhan HM, Theuvenet WJ. Operational value of serological measurements in multibacillary leprosy patients: clinical and bacteriological correlates of antibody responses. Int J Lepr Other Mycobact Dis. 1990 Sep;58(3):480-90
1989 Leprosy Diagnostics & Genetics Bothamley, GH. et al. (1989). Antibody responses to mycobacteria and their genetic control. Leprosy Research Reviews: 30-35.
1989 Leprosy Drugs (Compliance) Roche PW, Failbus S, Britton W. Self-administered drug compliance in Nepali leprosy patients. Trop Doct. 1989 Apr;19(2):59-61.
1989 Leprosy Diagnostics Roche, PW. et al. Comparison of antibody responses to carbohydrate and protein antigens in borderline tuberculoid leprosy. J. Nepal Medical Assn. 27: 57-61.
1989 Leprosy Diagnostics Roche, PW. et al. (1989). Serological responses to the specific glycolipid of Mycobacterium leprae in Nepali leprosy patients. J. Institute of Medicine (Kathmandu) 11: 197-204.
1987 Leprosy Drug Resistance Samuel NM, Samuel S, Adiga RB. Primary dapsone resistance in multibacillary leprosy among Nepalese children. Singapore Med J. 1987 Feb;28(1):28-30.
1986 Clinical Trial: Vaccination Samuel NM, Neupani K, Samuel S, Adiga RB. Vaccination of borderline tuberculoid leprosy patients with BCG plus killed Mycobacterium leprae. Nippon Rai Gakkai Zasshi. 1986 Apr-Jun;55(2):29-34.
1986 Clinical Trial: Leprosy Drugs Samuel NM, Samuel S, Adiga RB. Combined chemotherapy of multibacillary leprosy patients. Nippon Rai Gakkai Zasshi. 1986 Jul-Sep;55(3):65-71.
1985 Leprosy Photography Hattersley AT, Samuel S. Communicating with photographs in a leprosy hospital in Nepal. Lepr Rev. 1985 Dec;56(4):350-4.
1985 Clinical Trial: Vaccination Samuel NM, Neupani K, Loudon J, Samuel S. Vaccination of leprosy patients and healthy contacts. Indian J Lepr. 1985 Apr-Jun;57(2):288-96.
1985 Clinical Trial: Leprosy Drugs Samuel NM, Samual S, Fairbairn T, Adiga RB. Polytherapy in multibacillary leprosy patients in Nepal. Singapore Med J. 1985 Apr;26(2):203-6.
1985 Case Report: Child BL Samuel NM, Samuel S, Adiga RB. Borderline leprosy in a three year old child. Indian J Lepr. 1985 Jul-Sep;57(3):628-31.
1985 Clinical Trial: Leprosy Drugs Samuel NM, Samuel S, Adiga RB. Treatment of paucibacillary leprosy patients with dapsone and rifampicin. Nippon Rai Gakkai Zasshi. 1985 Oct-Dec;54(4):193-7.
1985 Clinical Trial: Vaccination Samuel NM, Silwal S, Samuel S, Loudon J. Identification of lymphocyte subsets in leprosin A positive sites following vaccination. Nippon Rai Gakkai Zasshi. 1985 Jan-Mar;54(1):18-24.
1985 Leprosy Diagnostics & Reactions Samuel NM, Stanford JL, Desikan KV. Microscopic findings of delayed reactions elicited by the skin test reagent Leprosin A derived from M. leprae. Int J Lepr Other Mycobact Dis. 1985 Sep;53(3):395-403.
1985 Leprosy Residual Bacilli Samuel NM. Acid fast bacilli in fingers and toes of long-treated lepromatous leprosy. Asian Medical Journal 1985, 28:568-579
1984 Leprosy Diagnostics Morton, A. et al. A further investigation of skin test responsiveness and suppression in leprosy patients and healthy school children in Nepal. Leprosy Review 1984, 55: 273-281.
1984 Leprosy Diagnostics Samuel NM, Adiga RB. Detection of antibodies in sera of leprosy patients and contacts by enzyme linked immunoabsorbent assay (ELISA). Nippon Rai Gakkai Zasshi. 1984 Jan-Mar;53(1):32-7. No abstract available.
1984 Basic Science: Leprosy Immunology Samuel NM, Mori S. Distribution of lymphocyte subsets in lymph nodes of leprosy patients. Nippon Rai Gakkai Zasshi. 1984 Oct-Dec;53(4):179-84.
1984 Leprosy Drug Resistance Samuel NM, Samuel S, Loudon J, Adiga RB. Primary dapsone resistant leprosy in Nepal. Indian J Lepr. 1984 Oct-Dec;56(4):819-22.
1984 Leprosy Drug Resistance Samuel NM, Samuel S, Loudon J, Neupani K, Adiga RB. Prevalence of secondary dapsone resistance in Nepal. Indian J Lepr. 1984 Oct-Dec;56(4):823-7.
1984 Leprosy Drugs Samuel NM, Samuel S, Nakami N, Murmu R. Multidrug treatment of leprosy--practical application in Nepal. Lepr Rev. 1984 Sep;55(3):265-72.
1984 Clinical Trial: Vaccination Samuel NM, Stanford JL, Rees RJ, Fairbairn T, Adiga RB. Human vaccination studies in normal and contacts of leprosy patients. Indian J Lepr. 1984 Jan-Mar;56(1):36-47.
1984 Case Report: nerve abcess Samuel S, Samuel NM, Thangaraj RH, Shreshta KB. Ulnar nerve calcification and abscess formation in two cases of primary mononeuritic leprosy. Lepr Rev. 1984 Jun;55(2):173-6.
1983 Basic Science: Lerposy Bacterial Culture Samuel, NM, et al. Growth of Mycobacterium leprae in nude mice. Leprosy in India 1983, 55:4